Overview
LIZTOX® 200 U is a purified Botulinum toxin type A injectable, formulated to smooth dynamic facial wrinkles and manage localized hyperactivity such as excessive sweating. Each vial contains 200 units of active toxin in a 30 g presentation.
Composition
- Clostridium botulinum toxin type A: 200 U
- Human serum albumin: 0.5 mg
- Sodium chloride: 0.9 mg
Mechanism of Action
By blocking acetylcholine release at the neuromuscular junction, LIZTOX® induces controlled muscle relaxation. This effect softens both fine and deep expression lines and prevents the formation of new wrinkles. When injected into sweat glands, it reduces excessive perspiration without systemic effects.
Indications
Cosmetic
- Moderate to severe glabellar (frown) lines
- Forehead wrinkles and interbrow lines
- Crow’s feet
- Marionette lines and necklines
Therapeutic
- Benign essential blepharospasm
- Hyperhidrosis (underarms, palms, soles)
- Chronic migraine prevention
- Muscle spasticity (e.g., cerebral palsy, post-stroke)
Dosage & Administration
- Reconstitution: Add sterile, preservative-free 0.9% saline; swirl gently to dissolve.
- Injection: Administer intramuscularly with a 30 G needle, dosing and sites tailored to the indication.
- Onset: Visible within 3–7 days.
- Duration: Effects last 2–8 months, depending on treatment area and individual response.
Storage
- Unopened vials: Refrigerate at 2–8 °C.
- Reconstituted solution: Store at 2–8 °C; use within 24 hours.
- Shelf life: 36 months from manufacture.
Advantages
- Ultra-high purity (> 99.8 %)
- Rapid onset and predictable duration
- Low risk profile with minimal adverse events
- Micro-papule technique for precise correction of fine lines
Safety & Precautions
Use only under the supervision of qualified healthcare professionals. Inspect reconstituted solution for clarity and absence of particulates. Common adverse effects include injection-site discomfort and transient muscle weakness; serious systemic reactions are rare but require immediate attention. Discard any unused product according to local regulations.
